KEGG   Canis lupus familiaris (dog): 403438
Entry
403438            CDS       T01007                                 
Symbol
MET
Name
(RefSeq) hepatocyte growth factor receptor precursor
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa04010  MAPK signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04020  Calcium signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04360  Axon guidance
cfa04510  Focal adhesion
cfa04520  Adherens junction
cfa05100  Bacterial invasion of epithelial cells
cfa05144  Malaria
cfa05200  Pathways in cancer
cfa05202  Transcriptional misregulation in cancer
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05211  Renal cell carcinoma
cfa05218  Melanoma
cfa05223  Non-small cell lung cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    403438 (MET)
   04014 Ras signaling pathway
    403438 (MET)
   04015 Rap1 signaling pathway
    403438 (MET)
   04020 Calcium signaling pathway
    403438 (MET)
   04151 PI3K-Akt signaling pathway
    403438 (MET)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    403438 (MET)
   04520 Adherens junction
    403438 (MET)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    403438 (MET)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    403438 (MET)
   05202 Transcriptional misregulation in cancer
    403438 (MET)
   05206 MicroRNAs in cancer
    403438 (MET)
   05205 Proteoglycans in cancer
    403438 (MET)
   05208 Chemical carcinogenesis - reactive oxygen species
    403438 (MET)
   05230 Central carbon metabolism in cancer
    403438 (MET)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    403438 (MET)
   05226 Gastric cancer
    403438 (MET)
   05218 Melanoma
    403438 (MET)
   05211 Renal cell carcinoma
    403438 (MET)
   05223 Non-small cell lung cancer
    403438 (MET)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    403438 (MET)
  09174 Infectious disease: parasitic
   05144 Malaria
    403438 (MET)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    403438 (MET)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    403438 (MET)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     403438 (MET)
Protein kinases [BR:cfa01001]
 Receptor tyrosine kinases (RTK)
  MET family
   403438 (MET)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr TIG Pkinase Sema PSI Kinase-like Pkinase_fungal Linker_histone TM_ErbB1
Other DBs
NCBI-GeneID: 403438
NCBI-ProteinID: NP_001002963
Ensembl: ENSCAFG00000003406
VGNC: 43166
UniProt: Q75ZY9
Position
14:55021838..55105272
AA seq 1382 aa
MKAPAVLAPGILVLLFTLVQKSYGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHKH
HIYLGAVNYIYVLNDKDLQKVAEYKTGPVLEHPDCSPCQDCSHKANLSGGVWEDNINMAL
LVDTYYDDQLISCGSVHRGTCQRHILPPSNIADIQSEVHCMYSSQADEEPSQCPDCVVSA
LGTKVLISEKDRFINFFVGNTINSSDHPDHSLHSISVRRLKETQDGFKFLTDQSYIDVLP
EFRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECI
LTEKRRKRSTREEVFNILQAAYVSKPGAHLAKQIGANLNDDILYGVFAQSKPDSAEPMNR
SAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARNDEYRTE
FTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGLSTPHVNF
RLDSHPVSPEAIVEHPLNQNGYTLVVTGKKITRIPLNGLGCEHFQSCSQCLSAPPFVQCG
WCHDRCVHLEECPTGAWTQEVCLPAIYEVFPTSAPLEGGTVLTVCGWDFGFRRNNKFDLK
KTKVFLGNESCTLTLSESTTNMLKCTVGPAVNEHFNISIIISNGRGTAQYSTFSYVDPII
TSISPSYGPKNGGTLLTLTGKYLNSGNSRHISMGGKTCTLKSVSDSILECYTPAQATATE
FPIKLKIDLANREMNSFSYQEDPIVYAIHPTKSFISGGSTITAVGKNLNSVSVLRMVIDV
HETRRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVMISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCETIYSDSKAVLCKVPND
LLKLNNELNIEWKQAVSSTVLGKVIVQPDQNFTGLIAGVISISTIVLLLLGLFLWLKRKK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNG
SCRQVQYPLTDLSPMLTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK
FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC
WHPRAELRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNIDGEG
DT
NT seq 4149 nt   +upstreamnt  +downstreamnt
atgaaggctcctgctgtgcttgcacctggcatccttgtgcttctgtttaccttggtgcag
aagagctatggggagtgcaaagaggcactagtaaagtctgagatgaatgtgaacatgaag
tatcagcttcccaacttcactgccgaaacacccatccagaatgttgttttacacaagcat
catatttaccttggtgcagttaactatatttacgttttaaatgacaaagaccttcagaag
gttgctgagtacaagactgggcccgtgctggaacacccagattgttccccatgtcaggac
tgcagccacaaagccaatttatcaggtggtgtttgggaagataacatcaacatggctctg
cttgttgacacatactacgatgaccaactcattagctgtggcagtgtccacagagggacc
tgccagcgacatatccttccacccagcaatattgctgacatacagtcggaagtgcattgc
atgtactcctcacaggcagacgaagagcccagccagtgccctgactgtgtggtgagtgct
ctaggaaccaaagtcctgatatcagaaaaggaccggttcatcaacttcttcgtaggcaat
accataaattcctcggaccatccagatcattcattgcattcgatatcggtgagaaggcta
aaggaaacgcaagatgggttcaagtttttgacagaccagtcttacattgatgttctaccg
gagttcagagactcctaccccattaaatatgtccacgcctttgaaagcaaccactttatt
tactttttgacagtccagcgagaaactctagatgctcagacttttcacacgagaataatc
aggttctgttctgtagactctggattgcattcctacatggaaatgcctctggagtgtatt
ctcacggaaaagagaagaaagagatccacaagggaggaagtgtttaatattctccaagct
gcatatgtcagtaagcctggggcccatctcgctaaacaaataggtgccaacctgaatgat
gacattctctatggagtgttcgcacaaagcaagccagattctgctgaaccaatgaatcgc
tctgccgtctgtgcgttccctatcaaatatgtcaatgaattcttcaacaagatcgtcaac
aaaaacaatgtgagatgtcttcagcacttttatggacccaaccacgaacactgctttaat
aggacacttttgagaaattcatcgggctgtgaagcgcgcaatgatgaatatcgaacggag
ttcactacagctttgcagcgcgttgacttattcatgggccagttcaaccaagtcctctta
acgtctatatccaccttcatcaaaggagacctcaccattgctaatcttgggacgtccgag
ggtcgcttcatgcaggtcgtggtttctcgatcaggattgtcgacccctcacgtgaacttc
cgcctggactcccaccccgtgtctccagaagcaattgtggagcacccactaaaccaaaac
ggctacacactcgttgtcactgggaagaagatcaccaggatcccactgaatggcttaggc
tgtgagcattttcagtcctgcagtcagtgtctctccgcccctccctttgtgcagtgtggc
tggtgccacgatagatgtgtgcacctggaggaatgtcccactggagcgtggactcaggag
gtctgtctgcctgcaatctatgaggttttcccaactagtgcacccctggaaggagggaca
gtgctgactgtatgtggctgggacttcggattcaggaggaataataaatttgatttaaag
aaaaccaaagttttccttggaaatgagagctgcaccttgaccttaagtgagagcacaaca
aatatgctgaaatgcacagttggccctgcagtgaacgagcatttcaatatatccataatt
atttcaaatggtcgagggacagcacaatatagtacattttcgtatgtggatcctattata
acaagtatttctccaagttatggtcccaagaatggtggcaccttgctcactttaactgga
aaatacctcaacagtgggaattctagacacatttcaatgggtggaaaaacatgtacttta
aaaagtgtgtcagatagtattctcgaatgttataccccagctcaagccactgcaactgag
tttcctattaaattgaaaattgacctagccaaccgagagatgaacagcttcagttaccag
gaagaccccattgtctatgcaattcatccaacgaaatcttttattagtggtgggagcaca
ataacagctgttggaaaaaacctgaattcagtgagtgtcctgaggatggtaatagatgtc
catgaaacaagaaggaactttacagtggcatgtcaacatcgctctaattcagagataatc
tgttgtacgactccttcactgcaacagctgaatctgcaactccctctgaaaaccaaagcc
tttttcatgttagatgggatccattccaaatactttgatctcatttatgtacataatcct
gtgtttaagccttttgaaaagccagtgatgatctcaataggcaatgaaaatgtactggaa
attaagggaaatgatattgaccctgaagcagttaaaggcgaagtgttaaaagttggaaat
aagagctgtgagactatctactcagattctaaagccgttttatgcaaggtccccaatgac
ctgctgaaattgaacaacgagctaaatatagagtggaagcaagcagtttcttcaaccgtc
cttggaaaagtaatagttcaaccagatcagaatttcacaggattgattgctggtgttatc
tcaatatcaacaatagtcttattattactcggacttttcctgtggctgaaaaggaaaaag
caaattaaagatctgggcagtgaattagttcgctatgatgcaagagtacacactcctcat
ttggataggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaa
tctgtagactaccgagctacttttccagaagaccagtttcctaattcatctcagaatgga
tcatgcagacaagtacaatatcctctgacggacctgtcccccatgcttactagtggggac
tctgatatatccagtccattattgcaaaatactgtccacattgacctcagtgctctaaat
ccagagctggtgcaggcagtccagcatgtagtgattgggcccagtagcctgattgtgcat
ttcaatgaagtcataggaagaggacattttgggtgtgtataccatgggactttgttggac
aatgacgacaaaaaaattcactgtgctgtgaaatccctgaatagaatcactgacatagga
gaagtttcccagtttctgaccgagggaatcatcatgaaagattttagtcatccaaacgta
ctctcactcttgggaatctgccttcgaagtgaggggtctccactggtggtcctaccatac
atgaaacatggagatcttcgaaatttcattagaaatgagactcataacccaactgtaaaa
gatcttattggctttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaag
tttgtccacagagacttggctgcaagaaactgtatgctggatgaaaaattcactgtcaag
gttgctgattttggtcttgccagagacatgtatgataaagaatactacagcgtacacaac
aaaacaggcgccaaactaccagtgaagtggatggctttagaaagtctgcaaactcagaag
tttaccaccaagtcagatgtgtggtcctttggcgtgctcctctgggaactgatgacaaga
ggagcaccaccttatcctgacgtcaacacctttgatataacagtttacttgttgcaaggc
agaaggctcctgcaacccgaatactgcccagatcccttatacgaagtgatgctaaaatgc
tggcaccctagagctgaactgcgcccatctttttctgaactggtctccaggatatcagca
atattctctactttcattggggagcactatgtccatgtgaacgccacttatgtgaatgtc
aaatgtgttgctccatacccttctctcttgtcatcacaagataacattgatggcgagggg
gacacatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (22)   
   KEGG PATHWAY (22)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (14)   
   RefSeq(nuc) (8)   
   GenBank (3)   
   EMBL (3)   
Protein domain (9)   
   Pfam (9)   
All databases (84)   

Download RDF
DBGET integrated database retrieval system